English | 2021 | ISBN: 3527343377 | 526 pages | True PDF EPUB | 47.74 MB
Discusses how to fightEbola, SARS Corona,and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades
Written by leading medicinal chemists from academia and industry, thisbookdiscusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets,and viral disease mechanisms.Itprovidesan outlook on emerging pathogens such as Ebola,Zika,West Nile, Lassa,and includes achapteronSARSCoronoavirus-2 causing the presentpandemic.
New Drug Development for Known and Emerging Virusesdescribes the discovery and development process for antiviral agents for different classes of viruses and targets based on theexperiencesfrom the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV,andVZV). It covers theproperties and potential of 20 classes of currently approved antivirals,including combination drugs, and looks at novel antiviral strategies against emerging viruses.
- Covers theentire field of antiviral drug discovery and developmentAddressestheneed forantiviral drugsto combatmajorhealththreatssuch asEbola, Zika,West Nile, andSARS Coronavirus-2Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angleDiscussespractical and strategic challenges in the drug discovery and development process, including screening technologies, latency,and toxicity issues
New Developments in Antiviral Drugsis animportantbook formedicinal chemists, pharmaceutical chemists, virologists,andepidemiologists, and willbe of great interest to those in thepharmaceutical industryandpublic health agencies.